Micronized Griseofulvin

Cardiovascular effects of griseofulvin.

The intravenous administration of griseofulvin in doses of 3.0 mg/kg to 32 anesthetized open-chest dogs produced marked increments (43%) in isometric systolic force measured by a strain gauge. These changes were accompanied by an increase (22%) in heart rate and a decrease (25%) in blood pressure. The effect was unaltered by clamping the blood supply to and from the adrenal glands or by previou...

The chemistry of griseofulvin.

Ketoconazole in griseofulvin-resistant dermatophytosis.

The efficacy of ketoconazole was evaluated in twenty patients with chronic dermatophyte infections who had failed to clear with griseofulvin therapy. Trichophyton rubrum was the causative organism in nineteen of the patients, and Trichophyton mentagrophytes in one patient. Three of twelve organisms tested showed in vitro resistance to griseofulvin. Duration of infection ranged from 2 to 28 year...

Raynaud's disease treated with griseofulvin.

The patient, a 7-year-old girl, with no previous history of circulatory disorder, developed rubella, and a week later a discoloration of her fingers was noted. The index finger of the right hand became purple and cold and then the index finger of her left hand became similarly affected. Other fingers were soon involved (see Fig.) and by the third week some discoloration of the toes was noticed....

Gris-peg (griseofulvin Ultramicrosize) Tablets, Usp

C17H17ClO 6 M.W. 352.77 Griseofulvin, USP occurs as a white to creamy white, odorless powder which is very slightly soluble in water, soluble in acetone, dimethylformamide, and chloroform and sparingly soluble in alcohol. Each Gris-PEG tablet contains: Active Ingredient: griseofulvin ultramicrosize................................................. 125 mg Inactive Ingredients: colloidal silicon d...